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Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin

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I rehearse two issues around the commentary of Whigham and colleagues. (1) There really are many more reasons than those given as to why natural evolution cannot reasonably find or select the 'optimal' individual. (2) A series of experimental molecular biology... ...