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[Preparation and evaluation of hydrophilic interaction/reversed-phase mixed-mode chromatographic packing based on polylsilsesquioxane microspheres]

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Hydrophilic interaction (HILIC)/reversed-phase (RPLC) mixed-mode chromatography is widely used in separating both hydrophobic and hydrophilic compounds, but its pH range is limited which is harmful to the separation of alkaline drugs. Monodispersed and porous ... ...