Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives
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Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild-type and ... ...
