Drugs and Scaffold That Inhibit Cytochrome P450 27A1 In Vitro and In Vivo
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Cytochrome P450 27A1 (CYP27A1) is a ubiquitous enzyme that hydroxylates cholesterol and other sterols. Complete CYP27A1 deficiency owing to genetic mutations is detrimental to human health, whereas 50% of activity retention is not and does not affect the whole... ...
