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ATP is stored in lamellar bodies to activate vesicular P2X4 in an autocrine fashion upon exocytosis

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Vesicular P2X4 receptors are known to facilitate secretion and activation of pulmonary surfactant in the alveoli of the lungs. P2X4 receptors are expressed in the membrane of lamellar bodies (LBs), large secretory lysosomes that store lung surfactant in alveol... ...