Demethylation of GFRA4 Promotes Cell Proliferation and Invasion in Hirschsprung Disease
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Hirschsprung disease (HSCR) is congenital intestinal aganglionosis attributed to a failure to migrate and survive of neural crest-derived cells. Glial cell-derived neurotrophic factor alpha 4 (GFRA4) is expressed in the derivatives of the neural crest in the e... ...