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Catalytic enantioselective synthesis of chiral organic compounds of ultra-high purity of >99% ee

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Shortly after the discovery of Zr-catalyzed carboalumination of alkynes in 1978, we sought expansion of the scope of this reaction so as to develop its alkene version for catalytic asymmetric C-C bond formation, namely the ZACA (Zr-catalyzed asymmetric carboal... ...