Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells
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Background: Mutations in the gene encoding Ubiquilin-2 (UBQLN2) are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). UBQLN2 plays a central role in ubiquitin proteasome system (UPS) and UBQLN2 muta... ...
