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Modelling of electrokinetic phenomena for capture of PEGylated ribonuclease A in a microdevice with insulating structures

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Synthesis of PEGylated proteins results in a mixture of protein-polyethylene glycol (PEG) conjugates and the unreacted native protein. From a ribonuclease A (RNase A) PEGylation reaction, mono-PEGylated RNase A (mono-PEG RNase A) has proven therapeutic effects... ...