Lymphocyte signaling and activation by the CARMA1-BCL10-MALT1 signalosome
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The CARMA1-BCL10-MALT1 (CBM) signalosome triggers canonical NF-κB signaling and lymphocyte activation upon antigen-receptor stimulation. Genetic studies in mice and the analysis of human immune pathologies unveiled a critical role of the CBM complex in adapti... ...
