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Review Cancers. 2016 Aug 20;8(8):76. doi: 10.3390/cancers8080076 Q24.42025

Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis

非酒精性脂肪肝相关肝癌发生发展的表观遗传激活Wnt/β-catenin信号通路机制研究 翻译改进

Yuan Tian  1, Myth T S Mok  2  3, Pengyuan Yang  4, Alfred S L Cheng  5  6  7

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作者单位

  • 1 Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. teresaty1987@163.com.
  • 2 School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. mythmok@mythmok.com.
  • 3 Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China. mythmok@mythmok.com.
  • 4 Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. pyyang@ibp.ac.cn.
  • 5 School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. alfredcheng@cuhk.edu.hk.
  • 6 Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, China. alfredcheng@cuhk.edu.hk.
  • 7 State Key Laboratory of Digestive Disease and Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China. alfredcheng@cuhk.edu.hk.

    • DOI: 10.3390/cancers8080076 PMID: 27556491

    摘要 Ai翻译

    Non-alcoholic fatty liver disease (NAFLD), characterized by fat accumulation in liver, is closely associated with central obesity, over-nutrition and other features of metabolic syndrome, which elevate the risk of developing hepatocellular carcinoma (HCC). The Wnt/β-catenin signaling pathway plays a significant role in the physiology and pathology of liver. Up to half of HCC patients have activation of Wnt/β-catenin signaling. However, the mutation frequ... ...点击完成人机验证后继续浏览
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    期刊名：Cancers

    缩写：CANCERS

    ISSN：N/A

    e-ISSN：2072-6694

    IF/分区：4.4/Q2

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    Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated Hepatocarcinogenesis