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A General and Practical Palladium-Catalyzed Direct α-Arylation of Amides with Aryl Halides

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An efficient system for the direct catalytic intermolecular α-arylation of acetamide derivatives with aryl bromides and chlorides is presented. The palladium catalyst is supported by Kwong's indole-based phosphine ligand and provides monoarylated amides in up... ...