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Effects of EPHX1 and CYP3A4 polymorphisms on carbamazepine metabolism in epileptic patients

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Background: The aim of this study was to investigate the effect of two genetic polymorphisms in the coding regions (exon 3 and exon 4) of the EPHX1 gene, ie, 337T>C and 416A>G, respectively, on the metabolism of carbamazepine (CB... ...