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Leucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 - 2013)

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Introduction: Leucine-rich repeat kinase 2 (LRRK2) is a large (2527 residues) complex multi-domain protein that has GTPase and kinase domains. Autosomal dominant missense mutations in LRRK2 have been found in individuals with Par... ...