Clinical pharmacology of ibuprofen and indomethacin in preterm infants with patent ductus arteriosus
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Background: Ibuprofen and indomethacin are potent non-selective cyclo-oxygenase inhibitors and inhibit prostaglandin E2 synthesis. The patent ductus arteriosus (PDA) occurs in more than 70% of preterm infants weighing <1500 g. Pr... ...
