Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates
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BACE1, a membrane-bound aspartyl protease that is implicated in Alzheimer's disease, is the first protease to cut the amyloid precursor protein resulting in the generation of amyloid-β and its aggregation to form senile plaques, a hallmark feature of the dise... ...
