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Carbohydrate polymers. 2014 Dec 19:114:183-189. doi: 10.1016/j.carbpol.2014.08.013 Q112.52025

MDG-1, a polysaccharide from Ophiopogon japonicus, prevents high fat diet-induced obesity and increases energy expenditure in mice

来自麦冬的多糖MDG-1可预防高脂饮食诱导的小鼠肥胖并增加能量消耗 翻译改进

Yuan Wang  1, Yunyun Zhu  1, Kefeng Ruan  1, Hai Wei  2, Yi Feng  3

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作者单位

  • 1 Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.
  • 2 TCM Syndrome and System Biology Research Center, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address: Wei_hai@hotmail.com.
  • 3 Engineering Research Center of Modern Preparation Technology of TCM, Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address: fyi_shutcm@163.com.

    • DOI: 10.1016/j.carbpol.2014.08.013 PMID: 25263880

    摘要 Ai翻译

    MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has potent hypoglycemic and weight control effects. We investigated the impact of MDG-1 on body weight, indirect calorimetry, body composition, plasma biochemical indices and obesity-related mitochondrial activity in diet-induced obese mice. Obese C57BL/6 mice induced by a high fat diet were given either vehicle or vehicle plus MDG-1 at 300 mg per body weight for 16-weeks. MDG-1 could evoked weight loss and reduce adipose tissue mass (by up to ∼ 50%) in the obese animals by increasing oxygen consumption and energy expenditure without inhibiting appetite or increasing physical activity. In addition, MDG-1 could ameliorate plasma lipid profiles, decrease leptin secretion, attenuate hepatic lipid accumulation and increased the expressions of genes related to lipid and energy metabolism in the liver. MDG-1 is a promising candidate drug to treat obesity-related metabolic diseases.

    Keywords: Anti-obesity; Diet induced obesity; Energy expenditure; Mitochondrial function; Ophiopogon japonicus; Polysaccharide.

    Keywords：high fat diet-induced obesity; energy expenditure

    关键词：麦冬多糖; 高脂饮食诱导的肥胖; 能量消耗

    Copyright © Carbohydrate polymers. 中文内容为AI机器翻译，仅供参考！

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    期刊名：Carbohydrate polymers

    缩写：CARBOHYD POLYM

    ISSN：0144-8617

    e-ISSN：1879-1344

    IF/分区：12.5/Q1

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    MDG-1, a polysaccharide from Ophiopogon japonicus, prevents high fat diet-induced obesity and increases energy expenditure in mice