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Transient receptor potential vanilloid type 1 antagonists: a patent review (2011 - 2014)

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Introduction: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that can be activated by noxious heat, low pH and vanilloid compounds such as capsaicin. Since TRPV1 acts as an integrator of pa... ...