Exome sequencing and array-based comparative genomic hybridisation analysis of preferential 6-methylmercaptopurine producers
{{output}}
Preferential conversion of azathioprine or 6-mercaptopurine into methylated metabolites is a major cause of thiopurine resistance. To seek potentially Mendelian causes of thiopurine hypermethylation, we recruited 12 individuals who exhibited extreme therapeuti... ...
