Introduction: Hyperuricemia has been described commonly in preeclamptic pregnancies, often preceding the diagnosis of preeclampsia and historically was used as a diagnostic marker of preeclampsia.

Objectives: The aim of this study was to determine the usefulness of uric acid to predict the preeclampsia on subsequent pregnancy.

Methods: The retrospective chart review was done. The pregnant women who had previous preeclampia or gestational hypertension and checked serum uric acid were enrolled in this study. Fifty-eight women were collected. Hyperuricemia was defined as being one standard deviation above the gestation-specific mean . And we used uric acid z-scores ([serum uric acid value - gestation specific mean]/standard deviation of the population) to account for gestation-specific alterations in uric acid and tested this as a continuous variable. Linear regression analysis was used to assess the relationship between gestation-corrected hyperuricemia and development of preeclampsia on subsequent pregnancy.

Results: Of 58 women, nineteen had the development of recurrent preeclampsia (37.5%). Linear regression analysis showed that the absence or presence of gestation-corrected hyperuricemia was not associated with the development of preeclampsia on subsequent pregnancy (p=0.353, 95% CI 0.418-11.520). And gestation-specific uric acid z-score as a continuous variable did not show any association with the prediction of preeclampsia on subsequent pregnancy (p=0.353, 95% CI 0.087-2.394).

Conclusion: Gestation-corrected hyperuricemia does not predict the development of preeclampsia on subsequent pregnancy.

Copyright © 2012. Published by Elsevier B.V.