首页 文献索引 SCI期刊 AI助手
登录 注册
首页 正文

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2015 Sep:38:46-51. doi: 10.1016/j.ijid.2015.07.005 Q14.82024

Risk factors for ventilator-associated pneumonia in patients with severe traumatic brain injury in a Serbian trauma centre

塞尔维亚一家创伤中心严重颅脑损伤患者呼吸机相关性肺炎的危险因素 翻译改进

Bojan Jovanovic  1, Zoka Milan  2, Ljiljana Markovic-Denic  3, Olivera Djuric  3, Kristina Radinovic  4, Krstina Doklestic  5, Jelena Velickovic  1, Nenad Ivancevic  5, Pavle Gregoric  5, Milena Pandurovic  6, Djordje Bajec  7, Vesna Bumbasirevic  1

作者单位 +展开

作者单位

  • 1 Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Centre for Anaesthesiology, Clinical Centre of Serbia, Belgrade, Serbia.
  • 2 King's College Hospital, London, SE5 9RS, UK. Electronic address: zoka.milan@kcl.ac.uk.
  • 3 Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • 4 Centre for Anaesthesiology, Clinical Centre of Serbia, Belgrade, Serbia.
  • 5 Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for Emergency Surgery, Clinical Centre of Serbia, Belgrade, Serbia.
  • 6 Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Centre for Anaesthesiology, Clinical Centre of Serbia, Belgrade, Serbia; "Medigroup" Hospital, Belgrade, Serbia.
  • 7 Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic for Digestive Surgery, Clinical Centre of Serbia, Belgrade, Serbia.
  • DOI: 10.1016/j.ijid.2015.07.005 PMID: 26166697

    摘要 Ai翻译

    Introduction: The aims of this study were (1) to assess the incidence of ventilator-associated pneumonia (VAP) in patients with traumatic brain injury (TBI), (2) to identify risk factors for developing VAP, and (3) to assess the prevalence of the pathogens responsible.

    Patients and methods: The following data were collected prospectively from patients admitted to a 24-bed intensive care unit (ICU) during 2013/14: the mechanism of injury, trauma distribution by system, the Acute Physiology and Chronic Health Evaluation (APACHE) II score, the Abbreviated Injury Scale (AIS) score, the Injury Severity Score (ISS), underlying diseases, Glasgow Coma Scale (GCS) score, use of vasopressors, need for intubation or cardiopulmonary resuscitation upon admission, and presence of pulmonary contusions. All patients were managed with a standardized protocol if VAP was suspected. The Sequential Organ Failure Assessment (SOFA) score and the Clinical Pulmonary Infection Score (CPIS) were measured on the day of VAP diagnosis.

    Results: Of the 144 patients with TBI who underwent mechanical ventilation for >48h, 49.3% did not develop VAP, 24.3% developed early-onset VAP, and 26.4% developed late-onset VAP. Factors independently associated with early-onset VAP included thoracic injury (odds ratio (OR) 8.56, 95% confidence interval (CI) 2.05-35.70; p=0.003), ISS (OR 1.09, 95% CI 1.03-1.15; p=0.002), and coma upon admission (OR 13.40, 95% CI 3.12-57.66; p<0.001). Age (OR 1.04, 95% CI 1.02-1.07; p=0.002), ISS (OR 1.09, 95% CI 1.04-1.13; p<0.001), and coma upon admission (OR 3.84, 95% CI 1.44-10.28; p=0.007) were independently associated with late-onset VAP (Nagelkerke r(2)=0.371, area under the curve (AUC) 0.815, 95% CI 0.733-0.897; p<0.001). The 28-day survival rate was 69% in the non-VAP group, 45.7% in the early-onset VAP group, and 31.6% in the late-onset VAP group. Acinetobacter spp was the most common pathogen in patients with early- and late-onset VAP.

    Conclusions: These results suggest that the extent of TBI and trauma of other organs influences the development of early VAP, while the extent of TBI and age influences the development of late VAP. Patients with early- and late-onset VAP harboured the same pathogens.

    Keywords: Injury; Neurotrauma; Pneumonia; Predictors.

    Keywords:risk factors; traumatic brain injury

    Copyright © International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:International journal of infectious diseases

    缩写:INT J INFECT DIS

    ISSN:1201-9712

    e-ISSN:1878-3511

    IF/分区:4.8/Q1

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Risk factors for ventilator-associated pneumonia in patients with severe traumatic brain injury in a Serbian trauma centre