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Clinical EEG and neuroscience. 2016 Apr;47(2):134-41. doi: 10.1177/1550059415603050 Q41.62024

Quantitative EEG of Rapid-Eye-Movement Sleep: A Marker of Amnestic Mild Cognitive Impairment

快速眼动睡眠的定量脑电图:一个遗忘性轻度认知障碍的标志 翻译改进

Pauline Brayet  1, Dominique Petit  2, Birgit Frauscher  3, Jean-François Gagnon  1, Nadia Gosselin  4, Katia Gagnon  1, Isabelle Rouleau  5, Jacques Montplaisir  6

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作者单位

  • 1 Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montreal, Montreal, Quebec, Canada Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
  • 2 Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montreal, Montreal, Quebec, Canada Department of Psychiatry, Université de Montréal, Montreal, Quebec, Canada.
  • 3 Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
  • 4 Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montreal, Montreal, Quebec, Canada Department of Psychology, Université de Montréal, Montreal, Quebec, Canada.
  • 5 Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada Neurology Service, Hôpital Notre-Dame du CHUM, Montreal, Quebec, Canada.
  • 6 Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montreal, Montreal, Quebec, Canada Department of Psychiatry, Université de Montréal, Montreal, Quebec, Canada jy.montplaisir@umontreal.ca.
  • DOI: 10.1177/1550059415603050 PMID: 26323578

    摘要 Ai翻译

    The basal forebrain cholinergic system, which is impaired in early Alzheimer's disease, is more crucial for the activation of rapid-eye-movement (REM) sleep electroencephalogram (EEG) than it is for wakefulness. Quantitative EEG from REM sleep might thus provide an earlier and more accurate marker of the development of Alzheimer's disease in subjects with mild cognitive impairment (MCI) subjects than that from wakefulness. To assess the superiority of the REM sleep EEG as a screening tool for preclinical Alzheimer's disease, 22 subjects with amnestic MCI (a-MCI; 63.9±7.7 years), 10 subjects with nonamnestic MCI (na-MCI; 64.1±4.5 years) and 32 controls (63.7±6.6 years) participated in the study. Spectral analyses of the waking EEG and REM sleep EEG were performed and the [(delta+theta)/(alpha+beta)] ratio was used to assess between-group differences in EEG slowing. The a-MCI subgroup showed EEG slowing in frontal lateral regions compared to both na-MCI and control groups. This EEG slowing was present in wakefulness (compared to controls) but was much more prominent in REM sleep. Moreover, the comparison between amnestic and nonamnestic subjects was found significant only for the REM sleep EEG. There was no difference in EEG power ratio between na-MCI and controls for any of the 7 cortical regions studied. These findings demonstrate the superiority of the REM sleep EEG in the discrimination between a-MCI and both na-MCI and control subjects.

    Keywords: Alzheimer’s disease; REM sleep; mild cognitive impairment; quantitative EEG; sleep.

    Keywords:quantitative eeg; rapid-eye-movement sleep; mild cognitive impairment

    Copyright © Clinical EEG and neuroscience. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Clinical eeg and neuroscience

    缩写:CLIN EEG NEUROSCI

    ISSN:1550-0594

    e-ISSN:

    IF/分区:1.6/Q4

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    Quantitative EEG of Rapid-Eye-Movement Sleep: A Marker of Amnestic Mild Cognitive Impairment