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Glucose metabolism in normal aging and Alzheimer's disease: Methodological and physiological considerations for PET studies

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Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder associated with progressive loss of cognitive function. 2-[18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) has long been used to measure resting-state cerebral metabo... ...