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Metabotropic glutamate receptor 5-positive allosteric modulators for the treatment of schizophrenia (2004-2012)

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The mGlu5, a class C G-protein-coupled receptor and member of the group I mGlu receptor family, has been demonstrated to play a role in a number of therapeutic areas within the CNS, including schizophrenia, dementia, epilepsy, cognition, drug abuse, and fragil... ...