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Journal of the American Society of Nephrology : JASN. 2014 Feb;25(2):232-7. doi: 10.1681/ASN.2013010077 Q19.42025

Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease

腺苷酸环化酶6缺陷可缓解多囊肾病 翻译改进

Sara Rees  1, Wararat Kittikulsuth, Karl Roos, Kevin A Strait, Alfred Van Hoek, Donald E Kohan

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  • 1 Division of Nephrology, University of Utah Health Sciences Center and Salt Lake City Veterans Affairs Medical Center, Salt Lake City, Utah.
  • DOI: 10.1681/ASN.2013010077 PMID: 24158982

    摘要 Ai翻译

    cAMP is an important mediator of cystogenesis in polycystic kidney disease (PKD). Several adenylyl cyclase (AC) isoforms could mediate cAMP accumulation in PKD, and identification of a specific pathogenic AC isoform is of therapeutic interest. We investigated the role of AC6 in a mouse model of PKD that is homozygous for the loxP-flanked PKD1 gene and heterozygous for an aquaporin-2-Cre recombinase transgene to achieve collecting duct-specific gene targeti... ...点击完成人机验证后继续浏览
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    期刊名:Journal of the american society of nephrology

    缩写:J AM SOC NEPHROL

    ISSN:1046-6673

    e-ISSN:1533-3450

    IF/分区:9.4/Q1

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    Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease