Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs). GPR120 is activated by unsaturated long-chain FFAs and has a crucial role in various physiological homeostasis mechanisms such as incretin hormone secretion and adipogenesis. Recent studies showed that a lipid sensor GPR120 has a key role in sensing dietary fat and in the control of energy homeostasis in both humans and rodents. Dysfunction of GPR120 is identified as a novel risk factor for diet-induced obesity. In this review, I provides recent development in the field and discusses its physiological roles and potential as drug targets.
Review Nihon rinsho. Japanese journal of clinical medicine. 2013 Feb;71(2):350-4.
[Diet-induced obesity and GPR120]
[饮食诱导的肥胖与GPR120] 翻译改进
Article in Japanese
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作者单位
PMID: 23631220
摘要 Ai翻译
Keywords：diet induced obesity
关键词：饮食诱导的肥胖
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