New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone
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Paget's disease of bone (PDB) is characterized by focal areas of aberrant and excessive bone turnover, specifically increased bone resorption and disorganized bone formation. Germline mutations in the sequestosome 1/p62 (SQSTM1/p62) gene are common in PDB pati... ...
