Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice
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Wild type (WT) activated protein C (APC) and cytoprotective-selective APC variants such as 3K3A-APC (<10% anticoagulant but normal cytoprotective activity) are neuroprotective in murine focal ischemic stroke models. Here we compared the neuroprotective effects... ...
