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Macromolecular crowding effect on cartilaginous matrix production: a comparison of two-dimensional and three-dimensional models

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Macromolecular crowding (MMC) has been shown to have a beneficial effect on production and maturation of extracellular matrices in a monolayer cell culture model. To explore its potential in tissue engineering, a mixture of Ficoll 70 and Ficoll 400 is used to ... ...