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Journal of the American Society of Nephrology : JASN. 2013 Mar;24(4):604-16. doi: 10.1681/ASN.2012050442 Q19.42025

TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease

TRPV4功能异常可促进常染色体隐性多囊肾病的肾脏囊肿形成 翻译改进

Oleg Zaika  1, Mykola Mamenko, Jonathan Berrout, Nabila Boukelmoune, Roger G O'Neil, Oleh Pochynyuk

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  • 1 Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
  • DOI: 10.1681/ASN.2012050442 PMID: 23411787

    摘要 Ai翻译

    The molecular mechanism of cyst formation and expansion in autosomal recessive polycystic kidney disease (ARPKD) is poorly understood, but impaired mechanosensitivity to tubular flow and dysfunctional calcium signaling are important contributors. The activity of the mechanosensitive Ca(2+)-permeable TRPV4 channel underlies flow-dependent Ca(2+) signaling in murine collecting duct (CD) cells, suggesting that this channel may contribute to cystogenesis in AR... ...点击完成人机验证后继续浏览
    Copyright © Journal of the American Society of Nephrology : JASN. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Journal of the american society of nephrology

    缩写:J AM SOC NEPHROL

    ISSN:1046-6673

    e-ISSN:1533-3450

    IF/分区:9.4/Q1

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    TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease