Desensitization, trafficking, and resensitization of the pituitary thyrotropin-releasing hormone receptor
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The pituitary receptor for thyrotropin-releasing hormone (TRH) is a calcium-mobilizing G protein-coupled receptor (GPCR) that signals through Gq/11, elevating calcium, and activating protein kinase C. TRH receptor signaling is quickly desensitized as a consequ... ...
