Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1
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Neurofibromatosis type-1 (NF1), resulting from NF1 gene loss of function, is characterized by an increased risk of developing benign and malignant peripheral nerve sheath tumors (MPNSTs). Whereas the cellular heterogeneity of NF1-associated tumors has been wel... ...