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Biophysical and structural investigation of bacterially expressed and engineered CCR5, a G protein-coupled receptor

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The chemokine receptor CCR5 belongs to the class of G protein-coupled receptors. Besides its role in leukocyte trafficking, it is also the major HIV-1 coreceptor and hence a target for HIV-1 entry inhibitors. Here, we report Escherichia coli expression and a b... ...