Characterization of bladder selectivity of antimuscarinic agents on the basis of in vivo drug-receptor binding
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The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed. Transdermal administration of oxybutynin in rats leads ... ...
