Probing water-protein contacts in a MMP-12/CGS27023A complex by nuclear magnetic resonance spectroscopy
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Using the case of the catalytic domain of MMP-12 in complex with the known inhibitor CGS27023A, a recently assembled 3D (15)N-edited/(14)N,(12)C-filtered ROESY experiment is used to monitor and distinguish protein amide protons in fast exchange with bulk water... ...
