Voltage-dependent sodium channel complexes consist of a pore-forming and voltage-sensing α-subunit and one or two β-subunits. The latter are type I transmembrane proteins with a broad spectrum of functions in channel expression and surface targeting, in channel electrophysiology and, notably, in cell-adhesion of excitable and non-excitable cells. Like the amyloid-precursor protein (APP), β-subunits are substrates for sequential cleavage either by α- an... ...

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