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Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD

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Oxidative damage is thought to be a major cause of the progression of dopamine (DA)rgic neurodegeneration as in Parkinson's disease. We have previously reported that tetrahydrobiopterin (BH4), an endogenous molecule required for DA synthesis, exerts oxidative ... ...