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The p75NTR extracellular domain: a potential molecule regulating the solubility and removal of amyloid-β

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Senile plaques composed of amyloid-beta (Aβ) in the brain are one of the hallmarks of Alzheimer disease (AD). Removal of Aβ from the brain is the most important therapeutic strategy for AD. The solubility of Aβ is critical for its endocytosis, transcytosis ... ...