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The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease

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The protozoan parasite Trypanosoma cruzi is the causative agent of human Chagas disease, for which there currently is no cure. The life cycle of T. cruzi is complex, including an extracellular phase in the triatomine insect vector and an obligatory intracellul... ...