Functional residual capacity and airway resistance in rats of COPD model induced by systemic hyaluronidase
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Chronic obstructive pulmonary disease (COPD) is characterized by obstructive bronchiolitis and parenchymal destruction. In animal models, air space enlargement induced by intratracheal elastase is augmented by prior depletion of lung hyaluronan by hyaluronisas... ...
