Functional characterization of NADP-dependent isocitrate dehydrogenase isozymes from Trypanosoma cruzi
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Trypanosoma cruzi exhibits two putative isocitrate dehydrogenases (IDHs). Both idh genes were cloned and the recombinant enzymes expressed in Escherichia coli. Our results showed that T. cruzi IDHs are strictly dependent on NADP(+) and display apparent affinit... ...
