Modulation of the p-glycoproein-mediated intestinal secretion of glibenclamide: in vitro and in vivo assessments
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The everted gut sac method was used to assess the role of the P-glycoprotein (P-gp) on the intestinal secretion of glibenclamide, a prototype of drug used to treat diabetic mellitus. The study included the evaluation of a P-gp modulator carbamazepine used at e... ...