In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi
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Geldanamycin (GA) is a benzoquinone-containing ansamycin that inhibits heat shock protein 90. GA derivatives are being evaluated as anti-neoplastic agents, but their utility against parasites whose heat shock proteins (Hsps) have homology with human Hsp90 is u... ...