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The Journal of physics and chemistry of solids. 2008 May;69(5-6):1533-1536. doi: 10.1016/j.jpcs.2007.10.043 Q24.32024

Mucoadhesive Microparticles Engineered for Ophthalmic Drug Delivery

用于眼部药物输送的黏膜粘附型微粒的设计与开发 翻译改进

Young Bin Choy  1, Jung-Hwan Park, Mark R Prausnitz

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作者单位

  • 1 School of Chemical and Biomolecular Engineering and Center for Drug Design, Development and Delivery, Georgia Institute of Technology, Atlanta, GA 30332-0100, USA.
  • DOI: 10.1016/j.jpcs.2007.10.043 PMID: 20657721

    摘要 Ai翻译

    Although topical drug delivery is a convenient route of administration to treat various eye diseases, it has serious limitations due to rapid clearance of the formulation from the surface of the eye. In this study, we engineered microparticles for both sustained drug delivery and prolonged residence time on the extraocular surface. Microparticles were fabricated by emulsification using poly(lactic-co-glycolic acid) (PLG) and poly(ethylene glycol) (PEG) as the core material and mucoadhesion promoter, respectively. The particle size was controlled to be less than 10 microm to avoid eye irritation and for eventual clearance through the lacrimal canals. In vitro mucoadhesion tests showed that PLG microparticles with PEG adhered better to the mucous membrane under the conditions employed in this study compared to the microparticles without PEG. When an aqueous suspension of microparticles with PEG was administered topically to the rabbit eye in vivo, microparticles were seen for up to 30 min on the ocular surface in the cul-de-sac, which was a dramatic increase in residence time as compared to conventional eye drop formulations. We conclude that mucoadhesive microparticles are promising vehicles for ophthalmic drug delivery.

    Keywords:mucoadhesive microparticles; ophthalmic drug delivery

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    期刊名:Journal of physics and chemistry of solids

    缩写:J PHYS CHEM SOLIDS

    ISSN:0022-3697

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    IF/分区:4.3/Q2

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