Intrauterine infection is a unique pathologic process that raises the risk for early-onset neonatal sepsis (EONS). By acting synergistically with prematurity, EONS increases the risk for adverse neonatal outcomes, including intraventricular hemorrhage and cerebral palsy. Although several pathways for the pathogenesis of fetal damage have been proposed, the basic molecular mechanisms that modulate these events remain incompletely understood. Discovery of clinically and biologically relevant biomarkers able to reveal key pathogenic pathways and predict pregnancies at risk for antenatal fetal damage is a priority. Proteomics provides a unique opportunity to fill this gap.
Review Clinics in perinatology. 2010 Jun;37(2):355-74. doi: 10.1016/j.clp.2010.03.002 Q32.92024
The role of proteomics in the diagnosis of chorioamnionitis and early-onset neonatal sepsis
蛋白质组学在胎盘炎和新生儿早期败血症诊断中的作用 翻译改进
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DOI: 10.1016/j.clp.2010.03.002 PMID: 20569812
摘要 Ai翻译
Keywords：proteomics; chorioamnionitis; neonatal sepsis
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