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In order to detect diseases like cancer at an early stage while it still may be curable, it's necessary to develop a diagnostic technique which can rapidly and inexpensively detect protein and nucleic acid biomarkers, without making any sacrifice in the sensitivity. We have developed a technique, based on the use of bioactivated microfluidic channels integrated with electrodes for electrical sensing, which can be used to detect protein biomarkers, target cells, and DNA hybridization. In this paper, we discuss the theoretical detection limits of this kind of sensor, and also discuss various experimental considerations in the electrical characterization of our device. In particular, we discuss the temperature dependence, the impedance drift, the noise sources, and various methods for optimizing the signal to noise ratio.
Journal of vacuum science & technology. B, Microelectronics and nanometer structures : processing, measurement, and phenomena : an official journal of the American Vacuum Society. 2009 Dec 4;27(6):3099-3103. doi: 10.1116/1.3264675 Q41.52024
Electrical Detection of Proteins and DNA using Bioactivated Microfluidic Channels: Theoretical and Experimental Considerations
用于生物活化微流体通道的蛋白质和DNA电学检测：理论与实验因素考虑 翻译改进
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DOI: 10.1116/1.3264675 PMID: 20467573
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