Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure led to significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than Lipofectamine 2000 or polyethylenimine for gene delivery to cancerous fibroblasts or human primary fibroblasts. These materials may be useful for cancer therapeutics and regenerative medicine.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009:2009:2412-5. doi: 10.1109/IEMBS.2009.5334767
Degradable polymers for gene delivery
可降解聚合物的基因传递功能研究进展 翻译改进
作者单位 +展开
作者单位
DOI: 10.1109/IEMBS.2009.5334767 PMID: 19964958
摘要 Ai翻译
Keywords：degradable polymers; gene delivery
相关内容
-
Degradable polymers via olefin metathesis polymerization
基于烯烃复分解聚合的可降解高分子材料研究进展
Progress in polymer science. 2021 Sep:120:101427.
-
Branched Macromolecular Architectures for Degradable, Multifunctional Phosphorus-Based Polymers
基于磷的可降解多功能聚合物的分支型大分子结构架
Macromolecular rapid communications. 2017 Feb;38(4).
-
Freeze-Dried Matrices Composed of Degradable Polymers with Surfactant-Loaded Microparticles Based on Pectin and Sodium Alginate
基于果胶和 sodium alginate 的含表面活性剂微粒的可降解聚合物冻干基质
Materials (Basel, Switzerland). 2021 Jun 3;14(11):3044.
-
Poly(phosphoester)s: A New Platform for Degradable Polymers
多(磷酯)：一种可降解聚合物的新平台
Angewandte Chemie (International ed. in English). 2015 May 18;54(21):6098-108.
-
Comparison of the properties of implantable matrices prepared from degradable and non-degradable polymers for bisphosphonate delivery
可降解和不可降解聚合物制备的双磷酸盐输送植入载体的性质比较
International journal of pharmaceutics. 2017 Nov 30;533(2):364-372.
-
Degradable polymer prodrugs with adjustable activity from drug-initiated radical ring-opening copolymerization
由药物控制的自由基共聚反应制备可降解聚合物前药及其活性调控研究
Chemical science. 2018 Sep 13;9(43):8291-8306.
-
Degradable polymers as biomaterials. Proceedings of the 459th Heraeus Seminar. Bad Honnef, Germany. May 30-June 2, 2010
可降解高分子材料作为生物医用材料的研究进展：第459期黑尔劳斯研讨会论文集，德国波登，2010年5月30日-6月2日
The International journal of artificial organs. 2011 Feb;34(2):71-252.
-
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization
通过可控环烯烃开环易位共聚合成可降解聚合物的万能方法
Nature chemistry. 2022 Jan;14(1):53-58.