Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
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The Philadelphia (Ph(1)) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients... ...