Interplays between covalent modifications in the endoplasmic reticulum increase conformational diversity in nascent prion protein
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Prion protein (PrP), the causative agent of transmissible spongiform encephalopathies, is synthesized in the endoplasmic reticulum (ER) where it undergoes numerous covalent modifications. Here we investigate the interdependence and regulation of PrP oxidative ... ...
