Isoaspartate-containing amyloid precursor protein-derived peptides alter efficacy and specificity of potential beta-secretases
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Neuritic plaques of Alzheimer patients are composed of multiple protein components. Among them, the amyloid beta-peptides (Abeta) 1-40/42 and further N- and C-terminally modified fragments of Abeta are highly abundant. Most prominent are the isoaspartate (isoA... ...
